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Article

IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHCII complexes.

Science advances - 12 Jul 2024

Qiu Zhijun, Khalife Jihane, Ethiraj Purushoth, Jaafar Carine, Lin An-Ping, Holder Kenneth N, Ritter Jacob P, Chiou Lilly, Huelgas-Morales Gabriela, Aslam Sadia, Zhang Zhao, Liu Zhijie, Arya Shailee, Gupta Yogesh K, Dahia Patricia L M, Aguiar Ricardo C T

Abstract excerpt

The mechanism by which interferon regulatory factor 8 (IRF8) mutation contributes to lymphomagenesis is unknown. We modeled IRF8 variants in B cell lymphomas and found that they affected the expression of regulators of antigen presentation. Expression of IRF8 mutants in murine B cell lymphomas suppressed CD4, but not CD8, activation elicited by antigen presentation and downmodulated CD74 and human leukocyte...

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Topics

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Share to Antigen Presentation
Share to Antigens, Differentiation, B-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Interferon Regulatory Factors

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Tumor Escape

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 38996030
DOI: 10.1126/sciadv.adk2091
PMCID: PMC11244530

Genes

CD4
CD74

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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