Article

Mechanistic insights into TLR7-mediated clinical outcome in COVID-19 and the potential modulatory role of N-acetylcysteine

2022-08-04

Abstract excerpt

Men with loss-of-function (LOF) variants of toll-like receptor 7 (TLR7) are more susceptible to critical COVID-19. We aimed to determine the pathogenicity and binding affinity changes of TLR7 variants towards SARS-CoV2 RNA, MyD88, imiquimod, and N-acetylcysteine (NAC). TLR7 deleterious mutations increase the risk of critical COVID-19 by 16-folds (95% CI: 2.40–106.73, p = 0.005). LOF-TLR7 variants had impaired SARS...

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Literature Corpus work: 14c40c71-228f-5bc8-8ccd-e3b44ea559a8
DOI: 10.21203/rs.3.rs-1920034/v1

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