Kidney ‘pathway-orphan’ genes as a potential overlooked source of novel insights into kidney health and disease

Abstract excerpt

<h4>ABSTRACT</h4> Hundreds of protein-coding genes still have unknown functions and no biological pathway annotations. Mechanistic studies typically investigate well-known genes, despite growing evidence of associations between disease and some understudied genes. We hypothesized that examining these overlooked genes lacking pathway annotation could lead to new insights on chronic kidney disease (CKD) pathogenesis...

Topics

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• Kidney Failure, Chronic
• Genome-Wide Association Study
• Glomerular Filtration Rate
• Polymorphism, Single Nucleotide
• Renal Insufficiency, Chronic
• Sequence Analysis, RNA
• Single-Cell Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

14c0e2cc-1f30-57cd-b2e0-44422e0f7aed

DOI

10.1101/2024.07.09.24309717