Integrative biology identifies shared transcriptional networks in CKD.

doi:10.1681/ASN.2013080906

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Article

Integrative biology identifies shared transcriptional networks in CKD.

Journal of the American Society of Nephrology : JASN - 1 Nov 2014

Martini Sebastian, Nair Viji, Keller Benjamin J, Eichinger Felix, Hawkins Jennifer J, Randolph Ann, Böger Carsten A, Gadegbeku Crystal A, Fox Caroline S, Cohen Clemens D, Kretzler Matthias

Abstract excerpt

A previous meta-analysis of genome-wide association data by the Cohorts for Heart and Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci associated with eGFR. To define how each of these single-nucleotide polymorphisms (SNPs) could affect renal function, we integrated GFR-associated loci with regulatory pathways, producing a molecular map of CKD. In kidney biopsy specimens from 157...

Topics

Adult
Aged
Databases, Genetic
Disease Progression
Female
Gene Regulatory Networks
Genome-Wide Association Study
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

North America

Polymorphism, Single Nucleotide

Renal Insufficiency, Chronic

Signal Transduction

Transcription, Genetic

Transcriptome

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24925724
DOI: 10.1681/ASN.2013080906
PMCID: PMC4214523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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