Article

Robust T Cell Responses to the Pfizer/Biontech Vaccine Compared to Infection and Evidence of Attenuated Cd8+ T Cell Responses Due to Covid-19

2022-07-26

Abstract excerpt

Using very sensitive “spheromer” peptide-MHC multimer reagents, we analyzed healthy subjects receiving two doses of the Pfizer/BioNTech BNT162b2 vaccine. Vaccination resulted in very robust peripheral blood responses to predicted SARS-CoV2 spike peptides bound to either class-I or class-II MHC alleles. These peaked at 9.8% and 7.5% for the dominant CD4+ (HLA-DRB1*15:01/S191) and CD8+ (HLA-A*02/S691) T cell epitope...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 14b5d69e-7c07-58d9-ae13-bf2af9929657
DOI: 10.2139/ssrn.4173451

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Robust T Cell Responses to the Pfizer/Biontech Vaccine Compared to Infection and Evidence of Attenuated Cd8+ T Cell Responses Due to Covid-19DOI 10.2139/ssrn.4173451Read

Robust T Cell Responses to the Pfizer/BioNTech Vaccine Compared to Infection and Evidence of Attenuated CD8 T Cell Responses Due to COVID-19Semantic proximity Read

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus VaccinesSemantic proximity Read

Multimodal characterization of antigen-specific CD8 <sup>+</sup> T cells across SARS-CoV-2 vaccination and infectionSemantic proximity Read

Protective Heterologous T Cell Immunity in COVID-19 Induced by MMR and Tdap Vaccine AntigensSemantic proximity Read

Real-world monitoring of BNT162b2 vaccine-induced SARS-CoV-2 B and T cell immunity in naive healthcare workers: a prospective single center studySemantic proximity Read

Systems biological assessment of human immunity to BNT162b2 mRNA vaccinationSemantic proximity Read

T cell response following anti COVID-19 BNT162b2 vaccination is maintained against the SARS-CoV-2 Omicron B.1.1.529 variant of concernSemantic proximity Read

Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 VaccineesSemantic proximity Read

Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigensSemantic proximity Read

Large libraries of single-chain trimer peptide-MHCs enable rapid antigen-specific CD8+ T cell discovery and analysisSemantic proximity Read

CMTM8 variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity.Semantic proximity Read

Extended interval BNT162b2 vaccination enhances peak antibody generation in older peopleSemantic proximity Read