Article

Protective Heterologous T Cell Immunity in COVID-19 Induced by MMR and Tdap Vaccine Antigens

2021-05-20

Abstract excerpt

T cells are critical for control of viral infection and effective vaccination. We investigated whether prior Measles-Mumps-Rubella (MMR) or Tetanus-Diphtheria-pertussis (Tdap) vaccination elicit cross-reactive T cells that mitigate COVID-19. Using co-cultures of antigen presenting cells (APC) loaded with antigens and autologous T cells, we found a high correlation between T cell responses to SARS-CoV-2 (Spike-S1 a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 990766d5-b899-5630-838c-cd8ea0c0b684
DOI: 10.2139/ssrn.3850361

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protective Heterologous T Cell Immunity in COVID-19 Induced by MMR and Tdap Vaccine AntigensDOI 10.2139/ssrn.3850361Read

Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigensSemantic proximity Read

T Cell Immune Responses to SARS-CoV-2 Infection and VaccinationSemantic proximity Read

Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigensSemantic proximity Read

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2Semantic proximity Read

T Cell Responses to SARS-CoV-2Semantic proximity Read

Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validationSemantic proximity Read

Role of antiviral CD8+ T cell immunity to SARS-CoV-2 infection and vaccinationSemantic proximity Read

Omicron Reactive Multi Protein Specific CD4 T Cells Defines Cellular Immune Response Induced by Inactivated Virus VaccinesSemantic proximity Read

Tissue-resident memory CD8 T-cell responses elicited by a single injection of a multi-target COVID-19 vaccineSemantic proximity Read

Clonal dissection of immunodominance and cross-reactivity of the CD4 <sup>+</sup> T cell response to SARS-CoV-2Semantic proximity Read

A Multi-Antigen Broad-Spectrum Coronavirus Vaccine Induces Potent and Durable Cross- Protection Against Infection and Disease Caused by Multiple SARS-CoV-2 VariantsSemantic proximity Read

Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individualsSemantic proximity Read