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Article

CMTM8 variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity.

Frontiers in immunology - 1 Jan 2026

Testori Alessandro, Mulas Antonella, Marongiu Mara, Orrù Valeria, Lobina Monia, Piras Maria Grazia, Lutzu Erika, Curreli Nicolò, Politi Cristina, Mobrici Marco, Iervasi Giorgio, Corda Daniela, De Felice Mario, Testa Alessandra, Devoto Marcella, Steri Maristella, Fiorillo Edoardo

Abstract excerpt

Background: The immunoglobulin level following vaccination against SARS-CoV-2 results from a multifaceted immunological process involving cells and molecules that determine its efficacy and protect us against severe infection outcomes. The observed heterogeneity in the immune response to vaccination is partly attributable to host genetic factors; however, this genetic contribution has only been partially...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41659846
DOI: 10.3389/fimmu.2026.1717058
PMCID: PMC12875989

Genes

CMTM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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