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Evaluating PFAS-Induced modulation of peripheral blood mononuclear cells (PBMCs) immune response to SARS-CoV-2 spike in COVID-19 Vaccinees

25 Mar 2025

Abstract excerpt

• A real life PFAS mixture was generated to understand its effect on immune cells activated with SARS-CoV-2 spike antigen. • High PFAS and SARS-CoV-2 spike exposure resulted in pro-inflammatory cytokine secretion by innate and adaptive cells in males. • High PFAS and SARS-CoV-2spike exposure lead to a decrease in total B cell frequency within PBMCs in females. • Pro-inflammatory chemokines MIP-1a (CCL3) and...

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Identifiers

PMID: 40147139
DOI: 10.1016/j.envint.2025.109409

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