Article

Systems biological assessment of human immunity to BNT162b2 mRNA vaccination

2021-04-22

Abstract excerpt

<title>Abstract</title> <p>The emergency use authorization of two COVID-19 mRNA vaccines in less than a year since the emergence of SARS-CoV-2, represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown. Here we used a systems biological approach to comprehensively profile the innate and adaptive immune responses in 56 healthy volun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 92cbf7c4-ee5f-50fe-bd0a-c2fa64aa861f
DOI: 10.21203/rs.3.rs-438662/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systems biological assessment of human immunity to BNT162b2 mRNA vaccinationDOI 10.21203/rs.3.rs-438662/v1Read

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responsesSemantic proximity Read

Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccineSemantic proximity Read

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.SSemantic proximity Read

Systemic IL-15, IFN-γ and IP-10/CXCL10 Signature Associated With Effective Immune Response in BNT162b2 mRNA Vaccine RecipientsSemantic proximity Read

Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cellsSemantic proximity Read

Baseline Enrichment of T and NK Cell Genes Predispose to mRNA Vaccine-Associated Systemic Adverse Events that Can Be Alleviated by Altering the Route of VaccinationSemantic proximity Read

Modulation of innate immune response to mRNA vaccination after SARS-CoV-2 infection or sequential vaccination in humansSemantic proximity Read

Discrete Immune Response Signature to SARS-CoV-2 mRNA Vaccination Versus InfectionSemantic proximity Read

Impact of BNT162b First Vaccination on the Immune Transcriptome of Elderly Patients Infected with the B.1.351 SARS-CoV-2 VariantSemantic proximity Read

BNT162b2 mRNA vaccine-induced sex differences in the single-cell transcriptome of peripheral blood mononuclear cells in healthy adultsSemantic proximity Read

Immune defects associated with lower SARS-CoV-2 BNT162b2 mRNA vaccine response in aged peopleSemantic proximity Read

High temporal resolution systems profiling reveals distinct patterns of interferon response after Covid-19 mRNA vaccination and SARS-CoV2 infectionSemantic proximity Read