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Differentiation-coupled intron retention reveals a candidate NKG2D-TR-like isoform at the murine Klrk1 locus

2026-08-25

Abstract excerpt

NKG2D (encoded by KLRK1 in humans and Klrk1 in mice) is an activating receptor expressed by cytotoxic lymphocytes. In humans, NKG2D signaling is regulated post-transcriptionally: activated T cells retain intron 4 of KLRK1 to generate NKG2D-TR, a truncated dominant-negative isoform that limits receptor signaling. Whether mice, the principal preclinical model for NKG2D-directed therapies, possess an analogous regula...

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Identifiers and source

Literature Corpus work
1494d4d1-c4b1-5822-a25b-778a945a1a31
DOI
10.64898/2026.08.21.746301
Open publication

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Differentiation-coupled intron retention reveals a candidate NKG2D-TR-like isoform at the murine Klrk1 locusDOI 10.64898/2026.08.21.746301
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