Article

Phytocarbon Dots as an Oral Nano-Degrader of ENO1 for Alleviating Hepatic Fibrosis

2026-07-03

Abstract excerpt

<title>Abstract</title> <p> The lack of clinically effective targeted therapies for hepatic fibrosis presents a persistent challenge. In this study, we introduce an innovative oral nanotherapeutic platform based on phytocarbon dots derived from <italic>Dianthus superbus</italic> (D‑CDs), which function as a target-specific protein degrader. D‑CDs demonstrated potent anti‑fibrotic efficacy in both toxin‑induced...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1490c689-b84d-59c7-8677-bbd3f490dff3
DOI: 10.21203/rs.3.rs-10125058/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phytocarbon Dots as an Oral Nano-Degrader of ENO1 for Alleviating Hepatic FibrosisDOI 10.21203/rs.3.rs-10125058/v1Read

Phytocarbon Nanodots Restore Glutathione Homeostasis via γ-Glutamylcysteine Synthetase against Ferroptosis-Driven Renal FibrosisSemantic proximity Read

Cancer cell membrane-coated PLGA nanoparticles deliver lupiwighteone to target EGFR and suppress hepatocellular carcinomaSemantic proximity Read

Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic InsightsSemantic proximity Read

Nanozymes for Non-neoplastic Diseases: Catalytic Therapy RedefinedSemantic proximity Read

Peptide Aptamer sP10 Targeting NPM1 Attenuates Liver Fibrosis and Hepatocellular CarcinomaSemantic proximity Read

A super-assembled synergistically nanoplatform AP@ZIF-8 Pt for hepatocarcinoma therapySemantic proximity Read

Sequential Ubiquitination and Phosphorylation Epigenetics Reshaping by MG132‐Loaded Fe‐MOF Disarms Treatment Resistance to Repulse Metastatic Colorectal CancerSemantic proximity Read

The pathophysiological mechanism of <i>Beni-koji Choleste-Help</i>/puberulic acid-induced kidney injury is proximal tubular mitochondrial dysfunctionSemantic proximity Read

Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cellsSemantic proximity Read

Anticipation and Verification of Dendrobium-Derived Nanovesicles for Skin Wound Healing Targets, Predicated Upon Immune Infiltration and SenescenceSemantic proximity Read

A noble TGFβ biogenesis inhibitor exhibits both potent anti-fibrotic and anti-inflammatory capabilitiesSemantic proximity Read

A BODIPY-naphtholimine-BF <sub>2</sub> dyad for precision photodynamic therapy, targeting and dual imaging of endoplasmic reticulum and lipid droplets in cancerSemantic proximity Read