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Bio-nanocomplexes impair iron homeostasis to induce non-canonical ferroptosis in cancer cells

19 Feb 2025

Abstract excerpt

The targeted elevation of the labile iron pool (LIP) represents the most direct and effective strategy to induce ferroptosis in cancer cells. However, the efficiency of increasing LIP to induce ferroptosis via iron supplementation is controversial due to the iron homeostasis between LIP and storage iron pool, leading to poor effects and serious safety concerns. In this study, a bio-nanocomplex named AbDA-Lim,...

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PMID: 39972473
DOI: 10.1186/s12951-025-03117-3

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