Article

Cancer cell membrane-coated PLGA nanoparticles deliver lupiwighteone to target EGFR and suppress hepatocellular carcinoma

2026-07-27

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is a globally prevalent malignancy with limited therapeutic options and dismal prognosis, highlighting an urgent need for novel agents and delivery strategies. Lupiwighteone, a natural prenylated isoflavone with potent anticancer properties, is severely hampered in clinical translation by its poor aqueous solubility and undefined mechanism against HCC. Rea...

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Literature Corpus work: 899e7aff-4f99-5bce-bf75-c9468ac341ba
DOI: 10.21203/rs.3.rs-10334645/v1

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