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Article

Effects of Single Mutations on Protein Stability Are Gaussian Distributed.

Biophysical journal - 16 Jun 2020

Razban Rostam M, Shakhnovich Eugene I

Abstract excerpt

The distribution of protein stability effects is known to be well approximated by a Gaussian distribution from previous empirical fits. Starting from first-principles statistical mechanics, we more rigorously motivate this empirical observation by deriving per-residue-position protein stability effects to be Gaussian. Our derivation requires the number of amino acids to be large, which is satisfied by the...

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Identifiers

PMID: 32416078
DOI: 10.1016/j.bpj.2020.04.027
PMCID: PMC7300273

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