Article

Mining signaling flow to interpret mechanisms of synergy of drug combinations using deep graph neural networks

2021-03-26

Abstract excerpt

Complex signaling pathways/networks are believed to be responsible for drug resistance in cancer therapy. Drug combinations inhibiting multiple signaling targets within cancer-related signaling networks have the potential to reduce drug resistance. Deep learning models have been reported to predict drug combinations. However, these models are hard to be interpreted in terms of mechanism of synergy (MoS), and thus...

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Literature Corpus work: 49882b4d-9929-5b4f-a69e-45793c3bc92c
DOI: 10.1101/2021.03.25.437003

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