Article
Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells.
Cancer cell - 9 Nov 2020
Kuenzi Brent M, Park Jisoo, Fong Samson H, Sanchez Kyle S, Lee John, Kreisberg Jason F, Ma Jianzhu, Ideker Trey
Abstract excerpt
Most drugs entering clinical trials fail, often related to an incomplete understanding of the mechanisms governing drug response. Machine learning techniques hold immense promise for better drug response predictions, but most have not reached clinical practice due to their lack of interpretability and their focus on monotherapies. We address these challenges by developing DrugCell, an interpretable deep learning...
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