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Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in <i>Cryptococcus neoformans</i>

2022-12-30

Abstract excerpt

Cryptococcus neoformans poses a threat to human health, but anticryptococcal therapy is hampered by the emergence of drug resistance, whose underlying mechanisms remain poorly understood. Herein, we discovered that Isw1, an imitation switch chromatin remodeling ATPase, functions as a master modulator of genes responsible for multidrug resistance in C. neoformans . Cells with the disrupted ISW1 gene exhibited pro...

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Literature Corpus work
51dc93d0-d174-5fad-b8e7-fbeb0d3d072f
DOI
10.1101/2022.12.30.522307
Open publication

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Interplay between acetylation and ubiquitination of imitation switch chromatin remodeler Isw1 confers multidrug resistance in <i>Cryptococcus neoformans</i>DOI 10.1101/2022.12.30.522307
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