Back to search

Article

Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohort

2021-12-15

Abstract excerpt

<p>Cardiometabolic risk factors (CMRs) are associated with accelerated brain aging and increased risk for sex-dimorphic illnesses such as Alzheimer’s Disease (AD). Yet, it is unknown how CMRs interact with sex and apolipoprotein E-ε4 (APOE4), a known genetic risk factor for AD, to influence brain age across different life stages. Using age prediction based on multi-shell diffusion-weighted imaging data in 21,308 U...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9e692552-671d-5578-849f-60d6ea0056d7
DOI
10.31234/osf.io/7xcun
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Sex- and age-specific associations between cardiometabolic risk and white matter brain age in the UK Biobank cohortDOI 10.31234/osf.io/7xcun
Multi-modality neuroimaging brain-age in UK Biobank: relationship to biomedical, lifestyle and cognitive factorsSemantic proximity
Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer’s diseaseSemantic proximity
Sex differences in brain aging among adults with family history of Alzheimer's disease and APOE4 genetic risk.Semantic proximity
Sex Differences in the Alzheimer’s Brain Age Gap: APOE ε4 Plays a Major RoleSemantic proximity
APOE4 and Chronic Health Risk Factors are Associated with Sex-Specific Preclinical Alzheimers Disease Neuroimaging BiomarkersSemantic proximity
Genome-wide analysis of brain age identifies 25 associated loci and unveils relationships with mental and physical healthSemantic proximity
Body fat and human cardiovascular ageingSemantic proximity
Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK BiobankSemantic proximity
Bio-psycho-social factors’ associations with brain age: a large-scale UK Biobank diffusion study of 35,749 participantsSemantic proximity
Hippocampal-to-Ventricle Ratio as a Head-Size-Independent Biomarker: Sex Differences and Cognitive Associations in 27,680 UK Biobank ParticipantsSemantic proximity
Joint multi-omics profiling of brain and body health in agingSemantic proximity
Brain aging comprises many modes of structural and functional change with distinct genetic and biophysical associationsSemantic proximity
Select a neighboring publication to make it the new centre.