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Article

A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways.

SLAS discovery : advancing life sciences R & D - 1 Jul 2017

Thomas Fiona M, Goode Kourtney M, Rajwa Bartek, Bieberich Andrew A, Avramova Larisa V, Hazbun Tony R, Davisson V Jo

Abstract excerpt

Compounds that modulate the heat shock protein (HSP) network have potential in a broad range of research applications and diseases. A yeast-based liquid culture assay that measured time-dependent turbidity enabled the high-throughput screening of different Saccharomyces cerevisae strains to identify HSP modulators with unique molecular mechanisms. A focused set of four strains, with differing sensitivities to...

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Source

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Identifiers

PMID: 28346089
DOI: 10.1177/2472555216687525
PMCID: PMC6521697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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