NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

doi:10.4049/jimmunol.172.4.2067

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Article

NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.

Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 2004

Kajiura Fumiko, Sun Shijie, Nomura Takashi, Izumi Keisuke, Ueno Tomoo, Bando Yoshimi, Kuroda Noriyuki, Han Hongwei, Li Yi, Matsushima Akemi, Takahama Yousuke, Sakaguchi Shimon, Mitani Tasuku, Matsumoto Mitsuru

Abstract excerpt

Physical contact between thymocytes and the thymic stroma is essential for T cell maturation and shapes the T cell repertoire in the periphery. Stromal elements that control these processes still remain elusive. We used a mouse strain with mutant NF-kappaB-inducing kinase (NIK) to examine the mechanisms underlying the breakdown of self-tolerance. This NIK-mutant strain manifests autoimmunity and disorganized...

Topics

Animals
Autoimmune Diseases
Bone Marrow Transplantation
CD4-Positive T-Lymphocytes
Cell Differentiation
Fetal Tissue Transplantation
Gene Expression Regulation, Developmental
Mice
Mice, Inbred A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred BALB C

Mice, Mutant Strains

Mice, Nude

Mutation

NF-kappa B

Organ Culture Techniques

Protein Serine-Threonine Kinases

Receptors, Interleukin-2

Self Tolerance

Source

Open in PubMed

Identifiers

PMID: 14764671
DOI: 10.4049/jimmunol.172.4.2067

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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