Article
Pinholin S21 mutations induce structural topology and conformational changes.
Biochimica et biophysica acta. Biomembranes - 1 Dec 2021
Ahammad Tanbir, Khan Rasal H, Sahu Indra D, Drew Daniel L, Faul Emily, Li Tianyan, McCarrick Robert M, Lorigan Gary A
Abstract excerpt
The bacteriophage infection cycle is terminated at a predefined time to release the progeny virions via a robust lytic system composed of holin, endolysin, and spanin proteins. Holin is the timekeeper of this process. Pinholin S21 is a prototype holin of phage Φ21, which determines the timing of host cell lysis through the coordinated efforts of pinholin and antipinholin. However, mutations in pinholin and...
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