Article

Retrograde Endocannabinoid Signaling Shows Robust Enrichment in Bipolar Disorder: Insights from Standardized Pathway Analyses

2026-03-08

Abstract excerpt

<title>Abstract</title> <p>Background and Rationale: Bipolar disorder is among the most heritable psychiatric conditions, yet its polygenic architecture is far from fully accounted for by models that foreground synaptic pruning and calcium signaling. The endocannabinoid system, which plays a well-documented role in modulating synaptic plasticity, stress reactivity, and affective stability, has received comparativ...

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Literature Corpus work: 13e80647-25a2-5a4a-b7d4-03a37657de51
DOI: 10.21203/rs.3.rs-8937137/v1

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