Article

A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

2025-07-10

Abstract excerpt

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a well-conserved enzyme across Archaea, Bacteria, and Eukarya, known not only for its canonical role in glycolysis, but also for diverse moonlighting functions including transcription regulation, host-pathogen interactions, and immune modulation. Studying GAPDH quantitatively is crucial for understanding how subtle variations at the sequence and structural levels...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13d04036-3090-5114-b3f6-4e7943a8c114
DOI: 10.1101/2025.07.06.663364

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Mathematical Genomics Perspective on the Moonlighting Role of Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)DOI 10.1101/2025.07.06.663364Read

Amino acid sequence encodes protein abundance shaped by protein stability at reduced synthesis cost.Semantic proximity Read

Evolution of Protein Regulation in the Vertebrate Glucose SensorSemantic proximity Read

Structure, function and stability analysis on potential deleterious mutation ensemble in glyceraldehyde 3-phosphate dehydrogenase (GAPDH) for early detection of LUAD.Semantic proximity Read

Structural studies of glyceraldehyde-3-phosphate dehydrogenase from Naegleria gruberi, the first one from phylum Percolozoa.Semantic proximity Read

Protein biophysics explains why highly abundant proteins evolve slowly.Semantic proximity Read

Coupling between Protein Stability and Catalytic Activity Determines Pathogenicity of G6PD Variants.Semantic proximity Read

Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin.Semantic proximity Read

Terminal regions of a protein are a hotspot for low complexity regions and selection.Semantic proximity Read

Protein dynamism and evolvability.Semantic proximity Read

Protein homeostasis imprinting across evolutionSemantic proximity Read

Proteins as Statistical Languages: Information-Theoretic Signatures of Proteomes Across the Tree of LifeSemantic proximity Read

Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins.Semantic proximity Read