Article
Mycobacterium tuberculosis Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Functions as a Receptor for Human Lactoferrin.
Frontiers in cellular and infection microbiology - 1 Jan 2017
Malhotra Himanshu, Patidar Anil, Boradia Vishant M, Kumar Rajender, Nimbalkar Rakesh D, Kumar Ajay, Gani Zahid, Kaur Rajbeer, Garg Prabha, Raje Manoj, Raje Chaaya I
Abstract excerpt
Iron is crucial for the survival of living cells, particularly the human pathogen Mycobacterium tuberculosis (M.tb) which uses multiple strategies to acquire and store iron. M.tb synthesizes high affinity iron chelators (siderophores), these extract iron from host iron carrier proteins such as transferrin (Tf) and lactoferrin (Lf). Recent studies have revealed that M.tb may also relocate several housekeeping...
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