Article

Host-directed therapy with 2-Deoxy-D-glucose inhibits human rhinoviruses, endemic coronaviruses, and SARS-CoV-2

2022-05-24

Abstract excerpt

<h4>ABSTRACT</h4> Rhinoviruses (RVs) and coronaviruses (CoVs) upregulate host cell metabolic pathways such as glycolysis to meet their bioenergetic demands for rapid multiplication. Using the glycolysis inhibitor 2-deoxy-D-glucose (2-DG), we assessed the dose-dependent inhibition of viral replication of minor- and major-receptor group RVs in epithelial cells. 2-DG disrupted RV infection cycle by inhibiting templa...

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Literature Corpus work: 13b52d13-ec12-55e6-8e9a-036afd6aa86c
DOI: 10.1101/2022.05.24.493068

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