PGC-1α mediates a metabolic host defense response in human airway epithelium during rhinovirus infections

Abstract excerpt

Human rhinoviruses (HRV) are common cold viruses associated with exacerbations of lower airways diseases. Although viral induced epithelial damage mediates inflammation, the molecular mechanisms responsible for airway epithelial damage and dysfunction remain undefined. Using experimental HRV infection studies in highly differentiated human bronchial epithelial cells grown at air-liquid interface (ALI), we examine...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antimicrobial Peptides and Activities
• Share to Asthma and respiratory diseases
• Share to Respiratory viral infections research