Article

Mapping the polymerization landscape of human serpins across genetic variation using Gaussian Processes

2026-08-25

Abstract excerpt

Proteins function on rugged energy landscapes that enable conformational plasticity but increase vulnerability to misfolding under genetic variation and stress. Serine protease inhibitors (serpins) are metastable proteins whose variants can polymerize and aggregate, causing diseases including emphysema, angioedema, thrombosis and dementia. Existing aggregation predictors underperform on serpin variants. Here, we p...

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Literature Corpus work: 138bc342-8156-5da3-b5d7-d6869418b00b
DOI: 10.65215/ltspreprints.2026.08.25.000315

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