Article

Covariant Fitness Clusters Reveal Structural Evolution of SARS-CoV-2 Polymerase Across the Human Population

2022-01-07

Abstract excerpt

Understanding the fitness landscape of viral mutations is crucial for uncovering the evolutionary mechanisms contributing to pandemic behavior. Here, we apply a Gaussian process regression (GPR) based machine learning approach that generates spatial covariance (SCV) relationships to construct stability fitness landscapes for the RNA-dependent RNA polymerase (RdRp) of SARS- CoV-2. GPR generated fitness scores captu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1344211c-bd1a-5c23-aeaa-544378e7788a
DOI: 10.1101/2022.01.07.475295

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Covariant Fitness Clusters Reveal Structural Evolution of SARS-CoV-2 Polymerase Across the Human PopulationDOI 10.1101/2022.01.07.475295Read

Biophysical principles predict fitness of SARS-CoV-2 variants.Semantic proximity Read

Triangulating variation in the population to define mechanisms for precision management of genetic disease.Semantic proximity Read

Quantifying Mutational Response to Track the Evolution of SARS-CoV-2 Spike Variants: Introducing a Statistical-Mechanics-Guided Machine Learning Method.Semantic proximity Read

Bridging Genomics to Phenomics at Atomic Resolution through Variation Spatial Profiling.Semantic proximity Read

Mapping the polymerization landscape of human serpins across genetic variation using Gaussian ProcessesSemantic proximity Read

PRIME: An evaluation framework for protein representation inference and generalization in viral mutation space.Semantic proximity Read

Secondary structure of the SARS-CoV-2 genome is predictive of nucleotide substitution frequencySemantic proximity Read

Co-evolution networks of HIV/HCV are modular with direct association to structure and function.Semantic proximity Read

Biophysical fitness landscape design traps viral evolutionSemantic proximity Read

Decomposing the sources of SARS-CoV-2 fitness variation in the United StatesSemantic proximity Read

Co-evolution networks of HIV/HCV are modular with direct association to structure and functionSemantic proximity Read

Constrained evolutionary funnels shape viral immune escape.Semantic proximity Read