Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Precision Medicine Targets in Glymphatic System Dysfunction: A Genomic and Molecular Perspective.

ACS chemical neuroscience - 15 Apr 2026

Wang Qihao, Gao Luqi, Yang Xiaoshan, Chen Bo, Li Wenchen, Wang Haifeng

Abstract excerpt

The genetic basis of traits linked to glymphatic system dysfunction (GSd) remains poorly understood. Using Genomic Structural Equation Modeling (Genomic-SEM) and multiple post Genome-Wide Association Studies (GWAS) methods, we identified four potentially genome-wide significant loci and one significant gene (Transmembrane protein 106B, TMEM106B). Transcriptome-wide analyses identified susceptibility gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genomics

Share to Nerve Tissue Proteins

Share to Precision Medicine

Source

Identifiers

PMID: 41874384
DOI: 10.1021/acschemneuro.5c00962

Genes

TMEM106B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Precision Medicine Targets in Glymphatic System Dysfunction: A Genomic and Molecular Perspective.PMID 41874384Read ↗

Most Monogenic Disorders Are Caused by Mutations Altering Protein Folding Free Energy.Semantic proximity Read ↗

Most monogenic disorders are caused by mutations altering protein folding free energySemantic proximity Read ↗

Genomic Structural Equation Modeling Provides an Initial View of the Genetic Architecture Related to Type 1 Gaucher Disease.Semantic proximity Read ↗

Molecular Insights into the Role of Pathogenic nsSNPs in GRIN2B Gene Provoking Neurodevelopmental Disorders.Semantic proximity Read ↗

Personalized biochemistry and biophysics.Semantic proximity Read ↗

Interpreting the molecular mechanisms of disease variants in human transmembrane proteinsSemantic proximity Read ↗

Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene<i>PSMC5</i>in neurodevelopmental proteasomopathiesSemantic proximity Read ↗

Some Mendelian Disorders could be fixed with a pill? A Structural Bioinformatic investigationSemantic proximity Read ↗

“The molecule’s the thing:” the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing resultsSemantic proximity Read ↗

Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains.Semantic proximity Read ↗

Computational Insights into the Deleterious Impacts of Missense Variants on N-Acetyl-d-glucosamine Kinase Structure and Function.Semantic proximity Read ↗

Protein molecular modeling techniques investigating novel TAB 2 variant R347X causing cardiomyopathy and congenital heart defects in multigenerational familySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.