Article

Managing the Spatial Covariance of Genetic Diversity in Niemann-Pick C1 Through Modulation of the Hsp70 Chaperone System

2018-10-09

Abstract excerpt

<h4>ABSTRACT</h4> Genetic diversity provides a rich repository for understanding the role of proteostasis in the management of the protein fold to allow biology to evolve through variation in the population and in response to the environment. Failure in proteostasis can trigger multiple disease states affecting both human health and lifespan. Niemann-Pick C (NPC) disease is a genetic disorder mainly caused by mut...

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Literature Corpus work: 8246221c-5580-5024-b0ec-c7c43e57b1a6
DOI: 10.1101/437764

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