Article

Estimating the mutation prevalence in the ageing human proteome

2026-04-06

Abstract excerpt

<title>Abstract</title> <p>Ageing is associated with a progressive accumulation of damaging mutations. Accordingly, a better understanding of the mutation prevalence in the ageing proteome is central to rationalizing many human diseases. Recent advances in artificial intelligence have enabled the accurate prediction of the effect of missense mutations at scale. Here, I test utility and limits of current genome-wi...

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Literature Corpus work: 2711fb39-f0d8-5905-9472-a265a5ce4cb5
DOI: 10.21203/rs.3.rs-9315156/v1

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