Article

Genetic-epigenetic tissue mapping for plasma DNA: applications in prenatal testing, transplantation and oncology

2020-11-13

Abstract excerpt

We developed G enetic- E pigenetic T issue Map ping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived. In lung-transplant recipi...

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Literature Corpus work: 1374c5a2-f85f-5c25-9817-1ff9f70e5c71
DOI: 10.1101/2020.11.13.381178

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