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Article

Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology.

eLife - 23 Mar 2021

Gai Wanxia, Zhou Ze, Agbor-Enoh Sean, Fan Xiaodan, Lian Sheng, Jiang Peiyong, Cheng Suk Hang, Wong John, Chan Stephen L, Jang Moon Kyoo, Yang Yanqin, Liang Raymond Hs, Chan Wai Kong, Ma Edmond Sk, Leung Tak Y, Chiu Rossa Wk, Valantine Hannah, Chan Kc Allen, Lo Ym Dennis

Abstract excerpt

We developed genetic-epigenetic tissue mapping (GETMap) to determine the tissue composition of plasma DNA carrying genetic variants not present in the constitutional genome through comparing their methylation profiles with relevant tissues. We validated this approach by showing that, in pregnant women, circulating DNA carrying fetal-specific alleles was entirely placenta-derived. In lung transplant recipients, we...

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Identifiers

PMID: 33752803
DOI: 10.7554/eLife.64356
PMCID: PMC7997656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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