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Article

Nuclear transplantation: lessons from frogs and mice.

Current opinion in cell biology - 1 Dec 2002

Hochedlinger Konrad, Jaenisch Rudolf

Abstract excerpt

Nuclear transplantation was developed 50 years ago in frogs to test whether nuclei from differentiated cells remain genetically equivalent to zygotic nuclei. Results from cloning experiments in frogs and mice indicate that nuclei gradually lose potency during development from embryonic to adult cells. However, even though adult mature lymphocytes were recently shown to remain genetically totipotent, no evidence...

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Identifiers

PMID: 12473349
DOI: 10.1016/s0955-0674(02)00380-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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