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Article

Hypermethylation of the GATA gene family in esophageal cancer

5 Jul 2006

Abstract excerpt

The GATA family of transcription factors promotes the normal development of the gastrointestinal tract during embryogenesis and determines tissue differentiation in adult gut epithelium. Loss of GATA-4 and GATA-5 has been reported in human gastric and colon cancer. We examined GATA-4,-5 and -6 gene expression in established esophageal squamous cancer cell lines and the relationship to DNA methylation in the...

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PMID: 16823849
DOI: 10.1002/ijc.22092

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