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Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa

11 Apr 2008

Abstract excerpt

BACKGROUND: Human gastrointestinal mucosa regenerates vigorously throughout life, but the factors controlling cell fate in mature mucosa are poorly understood. GATA transcription factors direct cell proliferation and differentiation in many organs, and are implicated in tumorigenesis. GATA-4 and GATA-6 are considered crucial for the formation of murine gastrointestinal mucosa, but their role in human...

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PMID: 18405344
DOI: 10.1186/1471-230x-8-9

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