Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting MYCN in Molecularly Defined Malignant Brain Tumors

28 Jan 2021

Abstract excerpt

Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found in malignant brain tumors highlighting their important roles as oncogenes. Brain tumors in children are the most lethal of all pediatric malignancies and the most common malignant primary adult brain tumor, glioblastoma, is still practically incurable. MYCN is one of three MYC family members and is crucial for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroblastoma Research and Treatments
Share to Protein Degradation and Inhibitors
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33585252
DOI: 10.3389/fonc.2020.626751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting MYCN in Molecularly Defined Malignant Brain TumorsPMID 33585252Read ↗

MYCN as an oncogene in pediatric brain tumorsSemantic proximity Read ↗

Biological Role of MYCN in Medulloblastoma: Novel Therapeutic Opportunities and Challenges AheadSemantic proximity Read ↗

Myc proteins in brain tumor development and maintenance.Semantic proximity Read ↗

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood CancersSemantic proximity Read ↗

The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic PotentialSemantic proximity Read ↗

Neuroblastoma and MYCN.Semantic proximity Read ↗

Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsSemantic proximity Read ↗

Taking on challenging targets: making MYC druggable.Semantic proximity Read ↗

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosisSemantic proximity Read ↗

MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formationSemantic proximity Read ↗

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer AmplificationSemantic proximity Read ↗

MYCN in Neuroblastoma: “Old Wine into New Wineskins”Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.