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Article

ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumors

3 Mar 2023

Abstract excerpt

Medulloblastoma, the most common malignant pediatric brain tumor, often harbors MYC amplifications. Compared to high-grade gliomas, MYC-amplified medulloblastomas often show increased photoreceptor activity and arise in the presence of a functional ARF/p53 suppressor pathway. Here, we generate an immunocompetent transgenic mouse model with regulatable MYC that develop clonal tumors that molecularly resemble...

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PMID: 36869047
DOI: 10.1038/s41467-023-36847-9

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