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USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STING

6 Aug 2022

Abstract excerpt

Pattern recognition receptors (PRRs) and interferons (IFNs) serve as essential antiviral defense against SARS-CoV-2, the causative agent of the COVID-19 pandemic. Type III IFNs (IFN-λ) exhibit cell-type specific and long-lasting functions in auto-inflammation, tumorigenesis, and antiviral defense. Here, we identify the deubiquitinating enzyme USP22 as central regulator of basal IFN-λ secretion and SARS-CoV-2...

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Inflammasome and immune disorders
interferon and immune responses
Viral Infections and Vectors

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35933402
DOI: 10.1038/s41419-022-05124-w

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