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Article

Whole transcriptome sequencing detects a large number of novel fusion transcripts in patients with AML and MDS.

Blood advances - 10 Nov 2020

Stengel Anna, Shahswar Rabia, Haferlach Torsten, Walter Wencke, Hutter Stephan, Meggendorfer Manja, Kern Wolfgang, Haferlach Claudia

Abstract excerpt

Fusion transcripts are frequent genetic abnormalities in myeloid malignancies and are often the basis for risk stratification, minimal residual disease (MRD) monitoring, and targeted therapy. We comprehensively analyzed the fusion transcript landscape in 572 acute myeloid leukemia (AML) and 630 myelodysplastic syndrome (MDS) patients by whole transcriptome sequencing (WTS). Totally, 274 fusion events (131 unique...

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Acute Myeloid Leukemia Research
Advanced biosensing and bioanalysis techniques
Chromosome Aberrations
Chronic Myeloid Leukemia Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome Sequencing

Leukemia, Myeloid, Acute

Myelodysplastic Syndromes

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Identifiers

PMID: 33147338
DOI: 10.1182/bloodadvances.2020003007
PMCID: PMC7656918

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