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Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

2022-12-14

Abstract excerpt

The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells (PGCs). Specifically, Floros et al. ( Nature Cell Biology 20: 144–51) reported an increase in the synonymity of mtDNA mutations (a sign of purifying selection)...

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Literature Corpus work: 131da3e4-1a7c-5aab-995f-838277bb49e9
DOI: 10.1101/2022.12.12.520138

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