Article
External contamination in single cell mtDNA analysis.
PloS one - 1 Aug 2007
Yao Yong-Gang, Bandelt Hans-Jürgen, Young Neal S
Abstract excerpt
BACKGROUND: Mitochondrial DNA (mtDNA) variation in single hematopoietic cells, muscle fibers, oocytes, and from tiny amount of tumor tissues and degraded clinical specimens has been reported in many medical publications. External DNA contamination, notoriously difficult to avoid, threatens the integrity of such studies. METHODOLOGY/PRINCIPAL FINDINGS: Employing a phylogenetic approach, we analyzed the geographic...
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