Article

Nuclear DNA-encoded fragments of mitochondrial DNA (mtDNA) confound analysis of selection of mtDNA mutations in human primordial germ cells

2021-10-19

Abstract excerpt

The resilience of the mitochondrial genome to a high mutational pressure depends, in part, on purifying selection against detrimental mutations in the germline. It is crucial to understand the mechanisms of this process. Recently, Floros et al. concluded that much of the purifying selection takes place during the proliferation of primordial germ cells (PGCs) because, according to their analysis, the synonymity of...

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Literature Corpus work: 0cb06bfb-8e9c-55e2-9957-3cb1bfd8b05f
DOI: 10.1101/2021.10.18.464832

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