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Article

Distal Mutations Rewire Allosteric Networks to Control Substrate Specificity in PTP1B.

Biochemistry - 16 Dec 2025

Wang Xiaoyuan, Anderson Ryan M, Liu Jinchan, Batista Victor, Loria J Patrick

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) is a key regulator of cellular signaling pathways, and its dysregulation is linked to diabetes, obesity, cancer, and immune dysfunction. While the catalytic mechanism of PTP1B is conserved across protein tyrosine phosphatases, its regulation by distal allosteric sites remains less understood. Here, we investigate how mutations at four allosteric sites (Y153, I275, M282, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41292192
DOI: 10.1021/acs.biochem.5c00539
PMCID: PMC12877921

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