Article

High-resolution double vision of the archetypal protein tyrosine phosphatase

2023-09-14

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) plays important roles in cellular homeostasis and is a highly validated therapeutic target for multiple human ailments including diabetes, obesity, and breast cancer. However, much remains to be learned about how conformational changes may convey information through the structure of PTP1B to enable allosteric regulation by ligands or functional responses to mutations. High-r...

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Literature Corpus work: 2bcebadf-3478-5d90-b986-c770a353014e
DOI: 10.1101/2023.09.12.557361

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