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Article

The mechanism of allosteric inhibition of protein tyrosine phosphatase 1B.

PloS one - 1 Jan 2014

Li Shuai, Zhang Jingmiao, Lu Shaoyong, Huang Wenkang, Geng Lv, Shen Qiancheng, Zhang Jian

Abstract excerpt

As the prototypical member of the PTP family, protein tyrosine phosphatase 1B (PTP1B) is an attractive target for therapeutic interventions in type 2 diabetes. The extremely conserved catalytic site of PTP1B renders the design of selective PTP1B inhibitors intractable. Although discovered allosteric inhibitors containing a benzofuran sulfonamide scaffold offer fascinating opportunities to overcome selectivity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24831294
DOI: 10.1371/journal.pone.0097668
PMCID: PMC4022711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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