Article

Angiogenin regulates mitochondrial stress and function via tRNA-derived fragments generation and impacting tRNA modifications

2024-02-14

Abstract excerpt

Mitochondrial stress and dysfunction play an important role in many diseases, such as cancer, diabetes, and neurodegenerative diseases. We previously observed that mitochondrial electron transport chain (ETC) inhibition can induce tRNA cleavage and tsRNAs (tRNA-derived small non-coding RNAs) generation. However, whether this process is mediated via Angiogenin (ANG), the canonical enzyme responsible for tRNA cleava...

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Literature Corpus work: 12e58096-acf0-5ecc-8c08-543978f84c6e
DOI: 10.1101/2024.02.13.580206

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