Article
Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs.
Molecular neurobiology - 1 Feb 2018
Li Siqi, Chen Yongdui, Sun Desen, Bai Rongpai, Gao Xiangwei, Yang Yi, Sheng Jinghao, Xu Zhengping
Abstract excerpt
Gene defects have been recognized as prominent factors in the etiology and pathogenesis of neurodegeneration. Among 60 neurodegeneration-related mutations in progranulin (PGRN), a mutation in PGRN gene exon 1 introduces a charged amino acid in the hydrophobic core of its signal peptide at residue 9 (named PGRN A9D) and results in incorrect cytoplasmic sorting. However, the pathogenesis of this mutation remains...
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