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Article

Microglia regulate cortical remyelination via TNFR1-dependent phenotypic polarization.

Cell reports - 26 Nov 2024

Boutou Athena, Roufagalas Ilias, Politopoulou Katerina, Tastsoglou Spyros, Abouzeid Maya, Skoufos Giorgos, Verdu de Juan Laia, Ko Jeong Hun, Kyrargyri Vasiliki, Hatzigeorgiou Artemis G, Barnum Christopher J, Tesi Raymond J, Bauer Jan, Lassmann Hans, Johnson Michael R, Probert Lesley

Abstract excerpt

Microglia are strongly implicated in demyelinating neurodegenerative diseases with increasing evidence for roles in protection and healing, but the mechanisms that control CNS remyelination are poorly understood. Here, we show that microglia-specific deletion of tumor necrosis factor receptor 1 (TNFR1) and pharmacological inhibition of soluble TNF (solTNF) or downstream interleukin-1 receptor (IL-1R) allow...

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PMID: 39446583
DOI: 10.1016/j.celrep.2024.114894

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