Article

Genetic diversity within diagnostic sputum samples is mirrored in the culture of <i>Mycobacterium tuberculosis</i>

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> Culturing Mycobacterium tuberculosis (MTB) from tuberculosis cases is the basis for many research and clinical applications. Paradoxically, it is assumed to impose a diversity bottleneck, which, if true, would entail unexplored consequences. The alternative, culture-free sequencing from diagnostic samples, is a promising but challenging approach both to obtain and analyse the MTB genome from th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12b36a6c-5889-5ef6-81fd-7629abeee91e
DOI: 10.1101/2024.01.30.577772

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic diversity within diagnostic sputum samples is mirrored in the culture of <i>Mycobacterium tuberculosis</i>DOI 10.1101/2024.01.30.577772Read

Genetic diversity within diagnostic sputum samples is mirrored in the culture of Mycobacterium tuberculosis across different settings.Semantic proximity Read

Direct nanopore sequencing of <i>M. tuberculosis</i> on sputa and rescue of suboptimal results to enhance transmission surveillanceSemantic proximity Read

Whole genome sequencing <i>Mycobacterium tuberculosis</i> directly from sputum identifies more genetic diversity than sequencing from cultureSemantic proximity Read

Within-host genetic micro-diversity of <i>Mycobacterium tuberculosis</i> and the link with tuberculosis disease featuresSemantic proximity Read

Comprehensive and accurate genetic variant identification from contaminated and low coverage <i>Mycobacterium tuberculosis</i> whole genome sequencing dataSemantic proximity Read

Culture-independent detection and characterisation of <i>Mycobacterium tuberculosis</i> and <i>M. africanum</i> in sputum samples using shotgun metagenomics on a benchtop sequencerSemantic proximity Read

Within-host pathogen population diversity predicts treatment response in TuberculosisSemantic proximity Read

In-host population dynamics of <i>M. tuberculosis</i> during treatment failureSemantic proximity Read

Effects of Host, Sample, and in vitro Culture on Genomic Diversity of Pathogenic MycobacteriaSemantic proximity Read

Whole genome sequencing Mycobacterium tuberculosis directly from sputum identifies more genetic diversity than sequencing from cultureSemantic proximity Read

Control of artefactual variation in reported inter-sample relatedness during clinical use of a <i>Mycobacterium tuberculosis</i> sequencing pipelineSemantic proximity Read

The MAGMA pipeline for comprehensive genomic analyses of clinical <i>Mycobacterium tuberculosis</i> samplesSemantic proximity Read